UCL 2077

Catalog # Availability Size / Price Qty
2661/10
2661/50

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UCL 2077 | CAS No. 918311-87-2 | Ca2+-Activated Potassium Channel Blockers
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Description: Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects

Chemical Name: N-Trityl-3-pyridinemethanamine

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice.

Technical Data

M.Wt:
350.46
Formula:
C25H22N2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
918311-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for UCL 2077

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2 Citations: Showing 1 - 2

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