UEV2 Antibody - BSA Free

Novus Biologicals | Catalog # NB100-56360

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all UBE2V2 Primary Antibodies »

Product Specifications

Immunogen

This antibody was generated by immunizing rabbit with a mixture of synthetic peptides containing amino acids 12-28 of human UBE2V2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UEV2 Antibody - BSA Free

Western Blot: UEV2 Antibody [NB100-56360]

Western Blot: UEV2 Antibody [NB100-56360]

Western Blot: UEV2 Antibody [NB100-56360] - Detection of UBE2V2 in HL-60 cell lysate with anti-UBE2V2 pcAb this antibody at 2ug/ml.

Applications for UEV2 Antibody - BSA Free

Application
Recommended Usage

Western Blot

2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBE2V2

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.

Long Name

Ubiquitin-conjugating Enzyme E2V 2

Alternate Names

DDVit-1, EDAF-1, EDPF1, MMS2, Uev2

Entrez Gene IDs

7336 (Human)

Gene Symbol

UBE2V2

UniProt

NP_003341 (Human)

Additional UBE2V2 Products

Product Documents for UEV2 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for UEV2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

NFkB Pathway

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