Catalog Number: 2466
Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Biological Activity
Water-soluble form of UK 14,304 (Cat. No. 0425). Full α2 adrenergic agonist. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    442.23
  • Formula:
    C11H10BrN5.C4H6O6
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    70359-46-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Specific [3H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α2-adrenergic selectivity and different affinities for GTP.
    Andorn et al.
    Life Sci., 1988;43:1805
  2. UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes.
    Cambridge
    Eur.J.Pharmacol., 1981;72:413
  3. Gene targeting - homing in on α2-adrenoceptor-subtype function.
    Macdonald et al.
    TiPS, 1997;18:211
  4. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
    Chopin et al.
    J.Pharmacol.Exp.Ther., 1999;288:798
Tocris Small Molecules
Description Application Cat# Citations Images  

UK 14,304

0425 3  
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