Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50
values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50
= 70 nM). Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary
on the SGC website.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Vedadi et al.
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
Liu et al.