Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Biological ActivityUNC 0638 is a selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Restores metabolic and antiviral function in exhausted CD8+ T cells from patients with chronic HCV infection. Cell permeable.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 0638 is reviewed on the chemical probes website.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Vedadi et al.
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
Liu et al.
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection.
Barili et al.
Citation for UNC 0638
The citations listed below are publications that use Tocris products. Selected citations for UNC 0638 include:
1 Citation: Showing 1 - 1
Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma.
Authors: Bellamy Et al.
Front Oncol 2020;10
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