UNC 0638

Catalog # Availability Size / Price Qty
4343/10
4343/50
UNC 0638 | CAS No. 1255580-76-7 | G9a/GLP Inhibitor
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Description: Selective G9a and GLP inhibitor

Chemical Name: 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). Potently inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Restores metabolic and antiviral function in exhausted CD8+ T cells from patients with chronic HCV infection. Cell permeable.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of UNC 0638 is reviewed on the chemical probes website.

Technical Data

M.Wt:
509.73
Formula:
C30H47N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1255580-76-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 0638 probe summary on the SGC website.

Product Datasheets

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Citation for UNC 0638

The citations listed below are publications that use Tocris products. Selected citations for UNC 0638 include:

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