UNC 3230

Catalog # Availability Size / Price Qty
UNC 3230 | CAS No. 1031602-63-7 | Other Kinase Inhibitors
1 Image
Description: Potent and selective PIP5K1C inhibitor; antinociceptive

Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide

Purity: ≥99%

Product Details
Citations (3)

Biological Activity

UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

Technical Data

Soluble to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The lipid kinase PIP5K1C regulates pain signaling and sensitization.
    Wright et al.
    Neuron, 2014;82:836

Product Datasheets

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Citations for UNC 3230

The citations listed below are publications that use Tocris products. Selected citations for UNC 3230 include:

3 Citations: Showing 1 - 3


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