Chemical Name: 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
Biological ActivityUNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.
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The lipid kinase PIP5K1C regulates pain signaling and sensitization.
Wright et al.
Citation for UNC 3230
The citations listed below are publications that use Tocris products. Selected citations for UNC 3230 include:
1 Citation: Showing 1 - 1
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer.
Authors: Peng Et al.
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