UNC 3230

Key Product Details

Product Description

UNC 3230 is a potent and selective PIP5K1C inhibitor (IC₅₀ = 41 nM). Exhibits selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. Reduces PIP₂ levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. Reduces nociception in mouse models of chronic pain.

Product Specifications for UNC 3230

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UNC 3230

The following data is based on the product molecular weight 344.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.90 mL	14.52 mL	29.03 mL
5 mM	0.58 mL	2.90 mL	5.81 mL
10 mM	0.29 mL	1.45 mL	2.90 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Wright The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron 2014 PMID: 24853942

Product Documents for UNC 3230