uPSEM 817 tartrate

Key Product Details

Product Description

uPSEM 817 tartrate is a selective ultrapotent PSEM (uPSEM) agonist for α7^{L131G,Q139L,Y217F}-GlyR (PSAM⁴-GlyR) and PSAM⁴-5-HT₃ chimeric ion channels (EC₅₀ values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM⁴-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM⁴-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg).

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Product Specifications for uPSEM 817 tartrate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for uPSEM 817 tartrate

The following data is based on the product molecular weight 419.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Magnus Ultrapotent chemogenetics for research and potential clinical applications. Science 2019 PMID: 30872534

Product Documents for uPSEM 817 tartrate