URB 597

Key Product Details

Product Description

URB 597 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC₅₀ values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.

Product Specifications for URB 597

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for URB 597

The following data is based on the product molecular weight 338.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.91 mL	29.55 mL	59.10 mL
2.5 mM	1.18 mL	5.91 mL	11.82 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
25 mM	0.12 mL	0.59 mL	1.18 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 67 publications citing the usage of this product.

• Piomelli Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev. 2006 PMID: 16834756
• Jayamanne Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. Br.J.Pharmacol. 2006 PMID: 16331291
• Hohmann An endocannabinoid mechanism for stress-induced analgesia. Nature 2005 PMID: 15973410

Product Documents for URB 597