URB 597

  ( 5 citations )    
Product Datasheet
Catalog Number:4612
Chemical Name:Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester
Product Details
Citations (5)
Reviews
Biological Activity
Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 3 and 5 nM in human liver and rat brain, respectively). Exhibits no significant inhibitory activity against a variety of receptors, ion channels and enzymes, including human cannabinoid receptors and rat monoacylglycerol lipase. Displays antiallodynic and antihyperalgesic activity in an inflammatory pain model.
Technical Data
  • M.Wt:
    338.4
  • Formula:
    C20H22N2O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    546141-08-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for URB 597 include:

5 Citations: Showing 1 - 5
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  1. Emotional arousal state influences the ability of amygdalar endocannabinoid signaling to modulate anxiety.
    Authors: Morena Et al.
    Neuropharmacology  2016;111:59
  2. Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine.
    Authors: Vilela Et al.
    J Neurosci  2015;2015:523418
  3. Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
    Authors: Sardinha Et al.
    Mediators Inflamm  2014;2014:978678
  4. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
    Authors: Butti Et al.
    Brain  2012;135:3320
  5. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action.
    Authors: Hamtiaux Et al.
    BMC Cancer  2012;12:92

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