Urolithin A

Tocris Bioscience | Catalog # 6762

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
Tocris Bioscience

Key Product Details

Description

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro
View all PI 3-Kinase Inhibitors »

Product Description

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Product Specifications for Urolithin A

Molecular Weight

228.20

Formula

C13H8O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one

CAS Number

1143-70-0

PubChem ID

5488186

InChI Key

RIUPLDUFZCXCHM-UHFFFAOYSA-N

SMILES

OC1=CC=C2C(OC(C3=CC(O)=CC=C23)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.82 100

Preparing Stock Solutions for Urolithin A

The following data is based on the product molecular weight 228.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.38 mL 21.91 mL 43.82 mL
5 mM 0.88 mL 4.38 mL 8.76 mL
10 mM 0.44 mL 2.19 mL 4.38 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Product Documents for Urolithin A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Urolithin A

For research use only

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