Urolithin A

Catalog # Availability Size / Price Qty
6762/50
6762/10
Urolithin A | CAS No. 1143-70-0 | PI 3-Kinase Inhibitors
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Description: PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one

Purity: ≥98%

Product Details
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Biological Activity

Urolithin A is a PI 3-K/Akt/mTOR signaling pathway inhibitor; blocks phosphorylation of Akt and p70S6K in pancreatic ductal adenocarcinoma (PDAC). Inhibits proliferation and migration and promotes apoptosis of PDAC cell lines in vitro (IC50 values are 10.23 - 62.28 μM). Suppresses tumor growth and improves survival in mice bearing pancreatic tumor xenografts. Also blocks amyloid-β fibrillation in vitro.

Technical Data

M.Wt:
228.2
Formula:
C13H8O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1143-70-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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