Catalog Number: 3303
Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
Biological Activity
RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
    le Maire et al.
    EMBO.Rep., 2009;10:367
  2. Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
    Santin et al.
    J.Med.Chem., 2009;52:3150
  3. Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function.
    Nahoum et al.
    Proc.Natl.Acad.Sci., 2007;104:17323
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