UVI 3003
Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
Purity: ≥98%
Biological Activity
UVI 3003 is a RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
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Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
Le Maire et al.
EMBO Rep., 2009;10:367 -
Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
Santin et al.
J.Med.Chem., 2009;52:3150 -
Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum et al.
Proc.Natl.Acad.Sci., 2007;104:17323
Product Datasheets
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Citations for UVI 3003
The citations listed below are publications that use Tocris products. Selected citations for UVI 3003 include:
4 Citations: Showing 1 - 4
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Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.
Authors: Hebert
Exp Cell Res 2017;361(1):101
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Clobetasol and halcin. Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.
Authors: Porcu Et al.
PLoS One 2015;10:e0144550
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Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.
Authors: Marconett Et al.
PLoS Genet 2013;9:e1003513
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AVNinduces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors.
Authors: Cambray Et al.
Nat Commun 2012;3:841
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