Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid
Biological ActivityRXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
Le Maire et al.
EMBO Rep., 2009;10:367
Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
Santin et al.
Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum et al.
Citations for UVI 3003
The citations listed below are publications that use Tocris products. Selected citations for UVI 3003 include:
4 Citations: Showing 1 - 4
Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.
Exp Cell Res 2017;361(1):101
Clobetasol and halcin. Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.
Authors: Porcu Et al.
PLoS One 2015;10:e0144550
Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.
Authors: Marconett Et al.
PLoS Genet 2013;9:e1003513
AVNinduces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors.
Authors: Cambray Et al.
Nat Commun 2012;3:841
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