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UVI 3003

3303 4 Citations Datasheet / COA / SDS
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UVI 3003 | CAS No. 847239-17-2 | Retinoid X Receptor Antagonists
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Description: RXR antagonist

Chemical Name: 3-[4-Hydroxy-3-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(pentyloxy)-2-naphthalenyl]phenyl]-2-propenoic acid

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

UVI 3003 is a RXR antagonist; displays high RXR binding affinity. Does not affect the corepressor interaction capacity of the RARα subunit within the context of the RAR-RXR heterodimer.

Technical Data

M.Wt:
436.58
Formula:
C28H36O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
847239-17-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.
    Le Maire et al.
    EMBO Rep., 2009;10:367
  2. Modulating retinoid X receptor with a series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
    Santin et al.
    J.Med.Chem., 2009;52:3150
  3. Modulators of the stuctural dynamics of the retinoid X receptor to reveal receptor function.
    Nahoum et al.
    Proc.Natl.Acad.Sci., 2007;104:17323

Product Datasheets

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Citations for UVI 3003

The citations listed below are publications that use Tocris products. Selected citations for UVI 3003 include:

4 Citations: Showing 1 - 4

  1. Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro.
    Authors: Hebert
    Exp Cell Res  2017;361(1):101
  2. Clobetasol and halcin. Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.
    Authors: Porcu Et al.
    PLoS One  2015;10:e0144550
  3. Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.
    Authors: Marconett Et al.
    PLoS Genet  2013;9:e1003513
  4. AVNinduces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors.
    Authors: Cambray Et al.
    Nat Commun  2012;3:841

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