Valsartan

Key Product Details

Product Description

Valsartan is a high affinity AT₁ receptor antagonist (K_i = 2.38 nM). Displays 30,000-fold selectivity over AT₂ receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active.

Product Specifications for Valsartan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Valsartan

The following data is based on the product molecular weight 435.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Wexler Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 1996 PMID: 8576904
• Hanafy Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 2008 PMID: 17965735
• Criscione Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT₁-receptor subtype. Br.J.Pharmacol. 1993 PMID: 8242249

Product Documents for Valsartan