VE 821

Catalog # Availability Size / Price Qty
6160/5
6160/25
Cat.No. 6160 - VE 821 | C18H16N4O3S | CAS No. 1232410-49-9
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Description: High affinity and selective ATP-competitive ATR inhibitor

Chemical Name: 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

High affinity and selective ATP-competitive ATR inhibitor (Ki = 13 nM). Exhibits >75-fold selectivity for ATR over related kinases mTOR, DNA-PK, PI 3-Kγ and PIKKs (Ki values are >1, 2.2, 3.9 and 16 μM, respectively) and a panel of other kinases. Induces cell death in colon cancer cell lines in vitro and sensitizes tumor cells to treatment with DNA damaging anticancer agents.

Technical Data

M.Wt:
368.41
Formula:
C18H16N4O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1232410-49-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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