Veliparib dihydrochloride

Catalog # Availability Size / Price Qty
Veliparib dihydrochloride | CAS No. 912445-05-7 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: High affinity PARP-1 and -2 inhibitor; orally bioavailable
Alternative Names: ABT-888

Chemical Name: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Veliparib dihydrochloride

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