Veliparib dihydrochloride

Tocris Bioscience | Catalog # 7026

High affinity PARP-1 and -2 inhibitor; orally bioavailable
Tocris Bioscience

Key Product Details

Description

High affinity PARP-1 and -2 inhibitor; orally bioavailable

Alternative Names

ABT-888
View all Poly(ADP-ribose) Polymerase Inhibitors »

Product Description

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

Product Specifications for Veliparib dihydrochloride

Molecular Weight

317.21

Formula

C13H16N4O.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride

CAS Number

912445-05-7

PubChem ID

45480520

InChI Key

DSBSVDCHFMEYBX-FFXKMJQXSA-N

SMILES

C[C@]1(C2=NC3=CC=CC(C(N)=O)=C3N2)CCCN1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.72 100
DMSO 31.72 100

Preparing Stock Solutions for Veliparib dihydrochloride

The following data is based on the product molecular weight 317.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.30 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for Veliparib dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Veliparib dihydrochloride

For research use only

Related Research Areas

Apoptosis

Citations for Veliparib dihydrochloride

Customer Reviews for Veliparib dihydrochloride (1)

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  • Veliparib dihydrochloride
    Name: Paras Gaur
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: human proteins
    Verified Customer | Posted 01/16/2025
    I used it in Mass Photometry experiments as an inhibitor for PARP1 PARylation. I used 75 nM of Veliparib concentration and we could see inhibition of PARP1 PARylation with both nicked and G-quadruplex DNA substrates.
    Veliparib dihydrochloride 7026

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