Venlafaxine hydrochloride

Key Product Details

Product Description

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K_i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Product Specifications for Venlafaxine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Venlafaxine hydrochloride

The following data is based on the product molecular weight 313.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.86 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Gould A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters. Biol.Psychiatry 2006 PMID: 16140280
• Bymaster Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 2001 PMID: 11750180
• Magalas The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 2005 PMID: 16325805

Product Documents for Venlafaxine hydrochloride