Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki
values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.
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The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats.
Magalas et al.
A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters.
Gould et al.
Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.
Bymaster et al.
The citations listed below are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:
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