Venlafaxine hydrochloride

Catalog # Availability Size / Price Qty
Venlafaxine hydrochloride | CAS No. 99300-78-4 | 5-HT Transporter Inhibitors
1 Image
Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: Wy 45030

Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

Purity: ≥99%

Product Details
Citations (3)
Supplemental Products

Biological Activity

Venlafaxine hydrochloride is a dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The serotonin/noradrenaline reuptake inhibitor venlaf. attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats.
    Magalas et al.
    Eur.J.Pharmacol., 2005;528:103
  2. A comparison of the chronic treatment effects of venlaf. and other antidepressants on serotonin and NE transporters.
    Gould et al.
    Biol.Psychiatry, 2006;59:408
  3. Comparative affinity of dulox. and venlaf. for serotonin and NE transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.
    Bymaster et al.
    Neuropsychopharmacol., 2001;25:871

Product Datasheets

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Citations for Venlafaxine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

3 Citations: Showing 1 - 3


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