VH 032, amine

Tocris Bioscience | Catalog # 6462

Functionalized VHL ligand for PROTACs
Tocris Bioscience

Key Product Details

Description

Functionalized VHL ligand for PROTACs
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Product Description

VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.

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PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

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Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for VH 032, amine

Molecular Weight

503.49

Formula

C22H30N4O3S.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

CAS Number

2137142-47-1

PubChem ID

118864076

InChI Key

SADPMNNWFOJMCY-ZNZDOTFASA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for VH 032, amine

Certificate of Analysis

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Product Specific Notices for VH 032, amine

For research use only

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