VH 032, amine

Catalog # Availability Size / Price Qty
6462/100
VH 032, amine | CAS No. 2137142-47-1 | Degrader Building Blocks
1 Image
Description: Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

Purity: ≥98%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

VH 032, amine is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC® that hijacks VHL as the E3 ubiquitin ligase component. Supplied with a primary amine functional handle at a position known not to significantly affect binding to VHL, for ready conjugation to a linker/target protein ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
503.49
Formula:
C22H30N4O3S.2HCl
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
2137142-47-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective small molecule induced degradation of the BET bromodomain protein BRD4.
    Zengerle et al.
    ACS Chem.Biol., 2015;10:1770
  2. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
    Galdeano et al.
    J.Med.Chem., 2014;57:8657

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for VH 032, amine

The citations listed below are publications that use Tocris products. Selected citations for VH 032, amine include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for VH 032, amine

There are currently no reviews for this product. Be the first to review VH 032, amine and earn rewards!

Have you used VH 032, amine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.