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Viomycin | Antibiotics
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Description: Antibiotic; inhibits bacterial DNA synthesis

Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

Product Details
Citations (4)

Biological Activity

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Technical Data

Soluble to 75 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. The allosteric three-site model for the ribosomal elongation cycle.
    Hausner et al.
    J.Biol.Chem., 1988;263:13103
  2. Modulation of RNA function by aminoglycoside antibiotics.
    Schroeder et al.
    EMBO J., 2000;19:1
  3. The antibiotic vio. traps the ribosome in an intermediate state of translocation.
    Ermolenko et al.
    Nat.Struct.Mol.Biol., 2007;14:493

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Viomycin

The citations listed below are publications that use Tocris products. Selected citations for Viomycin include:

4 Citations: Showing 1 - 4


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