Viomycin

Catalog # Availability Size / Price Qty
3787/10
Viomycin | Antibiotics
1 Image
Description: Antibiotic; inhibits bacterial DNA synthesis

Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate

Product Details
Citations (4)
Reviews (1)

Biological Activity

Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Technical Data

M.Wt:
881.85
Formula:
C25H43N13O10.2H2SO4
Solubility:
Soluble to 75 mM in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. The allosteric three-site model for the ribosomal elongation cycle.
    Hausner et al.
    J.Biol.Chem., 1988;263:13103
  2. Modulation of RNA function by aminoglycoside antibiotics.
    Schroeder et al.
    EMBO J., 2000;19:1
  3. The antibiotic vio. traps the ribosome in an intermediate state of translocation.
    Ermolenko et al.
    Nat.Struct.Mol.Biol., 2007;14:493

Product Datasheets

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Citations for Viomycin

The citations listed below are publications that use Tocris products. Selected citations for Viomycin include:

4 Citations: Showing 1 - 4

FAQs

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Reviews for Viomycin

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Viomycin and streptomycin were compared in inhibition of bacterial protein production
By Anonymous on 02/13/2019
Species: Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.


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