Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Biological ActivityViomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The allosteric three-site model for the ribosomal elongation cycle.
Hausner et al.
Modulation of RNA function by aminoglycoside antibiotics.
Schroeder et al.
EMBO J., 2000;19:1
The antibiotic vio. traps the ribosome in an intermediate state of translocation.
Ermolenko et al.
Citations for Viomycin
The citations listed below are publications that use Tocris products. Selected citations for Viomycin include:
4 Citations: Showing 1 - 4
Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer.
Authors: Abad Et al.
Mol Cell Proteomics 2018;
Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase.
Authors: Freihofer Et al.
PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
Authors: Samokhvalov Et al.
PLoS One 2015;232:44105
Molecular basis for the selectivity of antituberculosis compounds capreo. and vio.
Authors: Akbergenov Et al.
Antimicrob Agents Chemother 2011;55:4712
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Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.