Viomycin (CAS 32988-50-4): R&D Systems
Catalog Number: 3787
Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Biological Activity
Member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.
Technical Data
  • M.Wt:
    881.85
  • Formula:
    C25H43N13O10.2H2SO4
  • Solubility:
    Soluble to 75 mM in water
  • Storage:
    Store at -20°C
  • CAS No:
    32988-50-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Modulation of RNA function by aminoglycoside antibiotics.
    Schroeder et al.
    EMBO J., 2000;19:1
  2. The antibiotic viomycin traps the ribosome in an intermediate state of translocation.
    Ermolenko et al.
    Nat.Struct.Mol.Biol., 2007;14:493
  3. The allosteric three-site model for the ribosomal elongation cycle.
    Hausner et al.
    J.Biol.Chem., 1988;263:13103
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Viomycin include:

1 Citations: Showing 1 - 1

  1. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells.
    Authors: Samokhvalov Et al.
    PLoS One 2015;232:44105

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