VL 285

Tocris Bioscience | Catalog # 7903

VHL inhibitor
Tocris Bioscience

Key Product Details

Description

VHL inhibitor
View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

Product Specifications for VL 285

Molecular Weight

532.66

Formula

C29H32N4O4S

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number

1448188-57-5

PubChem ID

71667162

InChI Key

HEDFFPYRFJKXQP-VJTSUQJLSA-N

SMILES

CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 50
Ethanol 10.65 20

Preparing Stock Solutions for VL 285

The following data is based on the product molecular weight 532.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.75 mL 18.77 mL 37.55 mL
2.5 mM 0.75 mL 3.75 mL 7.51 mL
5 mM 0.38 mL 1.88 mL 3.75 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for VL 285

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VL 285

For research use only

Related Research Areas

E3 Ubiquitin Ligases

Customer Reviews for VL 285

There are currently no reviews for this product. Be the first to review VL 285 and earn rewards!

Have you used VL 285?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card