VTP 27999 trifluoroacetate

Key Product Details

Product Description

VTP 27999 trifluoroacetate is a highly potent and selective renin inhibitor (IC₅₀ = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).

Product Specifications for VTP 27999 trifluoroacetate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VTP 27999 trifluoroacetate

The following data is based on the product molecular weight 639.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.56 mL	7.82 mL	15.65 mL
5 mM	0.31 mL	1.56 mL	3.13 mL
10 mM	0.16 mL	0.78 mL	1.56 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lu Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 2014 PMID: 24637873
• Jia Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2011 PMID: 24900262

Product Documents for VTP 27999 trifluoroacetate