Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Biological ActivityPotent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Scott et al.
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
Lewis et al.
Citations for VU 0155069
The citations listed below are publications that use Tocris products. Selected citations for VU 0155069 include:
2 Citations: Showing 1 - 2
Elevated phopholipase D isoform 1 in Alzheimer's disease patient' hippocampus. Relevance to synaptic dysfunction and memory deficits.
Authors: Krishnan Et al.
Alzheimers Dement (N Y) 2018;4:89
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
Authors: Sulzmaier Et al.
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