Home / Group I mGluR Modulators / VU 0360172 hydrochloride

VU 0360172 hydrochloride

Catalog #: 4323
1 Citation Datasheet / COA / SDS
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4323/10
4323/50
VU 0360172 hydrochloride | CAS No. 1309976-62-2 | Group I mGluR Modulators
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Description: Positive allosteric modulator of mGlu5 receptors

Chemical Name: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

VU 0360172 hydrochloride is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Technical Data

M.Wt:
330.78
Formula:
C18H15FN2O.HCl
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1309976-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for VU 0360172 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for VU 0360172 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Positive modulation of mGluR5 attenuates seizures and reduces TNF-α+ macrophages and microglia in the brain in a murine model of virus-induced temporal lobe epilepsy.
    Authors: Hanak Et al.
    Exp.Neurol.  2019;311:194

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VersaClone cDNA Plasmids

Human mGluR5 (NP_000833) VersaClone cDNA

RDC1064

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