VU 0360172 hydrochloride

Catalog # Availability Size / Price Qty
4323/10
4323/50
Cat.No. 4323 - VU 0360172 hydrochloride | C18H15FN2O.HCl | CAS No. 1309976-62-2
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Description: Positive allosteric modulator of mGlu5 receptors

Chemical Name: N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride

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Biological Activity

Positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). Selective for mGlu5; displays no significant activity at mGlu1, mGlu2 or mGlu4 receptors. Exhibits antipsychotic-like activity in a rodent model. Also reduces spontaneous spike and wave discharges without affecting motor behaviour in a rat model of absence epilepsy.

Technical Data

Formula:
C18H15FN2O.HCl
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1309976-62-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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