VU 0364739 hydrochloride

  ( 6 citations )    
Product Datasheet
Catalog Number:4171
Chemical Name:N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Product Details
Citations (6)
Reviews
Biological Activity
Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).
Technical Data
  • M.Wt:
    482.98
  • Formula:
    C26H27FN4O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    1244640-48-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

6 Citations: Showing 1 - 6
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  1. Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits.
    Authors: Krishnan Et al.
    Alzheimer Dement (N Y)  2018;4:89
  2. Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.
    Authors: Chelakkot Et al.
    Sci Rep  2017;7:1573
  3. PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division.
    Authors: Liu Et al.
    PeerJ  2017;5:e3295
  4. Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
    Authors: Jiang Et al.
    J Biol Chem.  2016;291:20729
  5. Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment.
    Authors: Martínez-Martínez Et al.
    PLoS One  2014;9:e111685
  6. The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.
    Authors: Basiouni Et al.
    Autophagy  2013;14:9005

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