VU 0364739 hydrochloride
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98%
Biological Activity
VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
Lavieri et al.
J.Med.Chem., 2010;53:6709
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Citations for VU 0364739 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:
8 Citations: Showing 1 - 8
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Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation.
Authors: Bich Et al.
Sci Rep 2018;8:6283
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An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets.
Authors: Lu Et al.
J Clin Med 2018;7
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Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits.
Authors: Krishnan Et al.
Alzheimer Dement (N Y) 2018;4:89
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Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.
Authors: Chelakkot Et al.
Sci Rep 2017;7:1573
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PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division.
Authors: Liu Et al.
PeerJ 2017;5:e3295
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Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
Authors: Jiang Et al.
J Biol Chem. 2016;291:20729
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Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment.
Authors: Martínez-Martínez Et al.
PLoS One 2014;9:e111685
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The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.
Authors: Basiouni Et al.
Autophagy 2013;14:9005
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