Catalog Number: 4171
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Biological Activity
Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).
Technical Data
  • M.Wt:
    482.98
  • Formula:
    C26H27FN4O2.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1244640-48-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
    Lavieri et al.
    J.Med.Chem., 2010;53:6709
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
    Authors: Jiang Et al.
    J Biol Chem. 2016;291:20729
  2. The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells.
    Authors: Basiouni Et al.
    Autophagy 2013;14:9005

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