VU 0364739 hydrochloride

Catalog # Availability Size / Price Qty
4171/10
4171/50
Phospholipase Inhibitors Small Molecule
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Description: Potent and selective PLD2 inhibitor

Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide

Purity: ≥98%

Product Details
Citations (8)
Reviews

Biological Activity

Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

Technical Data

M.Wt:
482.98
Formula:
C26H27FN4O2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1244640-48-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.
    Lavieri et al.
    J.Med.Chem., 2010;53:6709

Product Datasheets

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Citations for VU 0364739 hydrochloride

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