VU 0422288

Catalog # Availability Size / Price Qty
5378/10
5378/50
Cat.No. 5378 - VU 0422288 | C17H11Cl2N3O2 | CAS No. 1630936-95-6
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Description: Selective group III mGlu positive allosteric modulator
Alternative Names: ML 396

Chemical Name: N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide

Purity: ≥98%

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Biological Activity

Group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.

Technical Data

M.Wt:
360.19
Formula:
C17H11Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1630936-95-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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