Catalog Number: 4719
Chemical Name: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
Biological Activity
Potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC50 = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters.
Technical Data
  • M.Wt:
    382.5
  • Formula:
    C19H18N4OS2
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1391737-01-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe.
    Delpire et al.
    Bioorg.Med.Chem.Lett., 2012;22:4532
  2. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.
    Sivakumaran et al.
    J.Neurosci., 2015;35:8291
Citations:

The citations listed below are publications that use Tocris products. Selected citations for VU 0463271 include:

2 Citations: Showing 1 - 2
Filter your results:

  1. Cl- out is a novel cooperative optogenetic tool for extruding chloride from neurons
    Authors: Alfonsa Et al.
    Nature Communications 2016;7:13495
  2. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Mol Syst Biol 2015;8:35

Have you used VU 0463271?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information