VU 0463271

Key Product Details

Product Description

VU 0463271 is a potent and selective inhibitor of the neuronal K-Cl cotransporter, KCC2 (IC₅₀ = 61 nM); displays >100-fold selectivity versus the Na-K-2Cl cotransporter 1 (NKCC1) and no activity against a panel of 68 GPCRs, ion channels and transporters.

Product Specifications for VU 0463271

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0463271

The following data is based on the product molecular weight 382.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.23 mL	26.14 mL	52.29 mL
2.5 mM	1.05 mL	5.23 mL	10.46 mL
5 mM	0.52 mL	2.61 mL	5.23 mL
25 mM	0.10 mL	0.52 mL	1.05 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 36 publications citing the usage of this product.

• Sivakumaran Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J.Neurosci. 2015 PMID: 26019342
• Delpire Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg.Med.Chem.Lett. 2012 PMID: 22727639

Product Documents for VU 0463271