Selective renal outer medullary potassium channel (Kir
1.1, ROMK) antagonist (IC50
= 300 nM). Thought to block the intracellular pore of the Kir
1.1 channel. Exhibits no effect on Kir
7.1 at concentrations up to 10 μ
M; does not inhibit Kir
2.3 or Kir
4.1. Displays similar potency to VU 590
(Cat. No. 3891).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Bhave et al.