VU 591 hydrochloride

Catalog # Availability Size / Price Qty
4197/10
4197/50
VU 591 hydrochloride | CAS No. 1315380-70-1 | Inward Rectifier Potassium Channel Blockers
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Description: Selective Kir1.1 (ROMK) inhibitor

Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).

Technical Data

M.Wt:
404.76
Formula:
C16H12N6O5.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1315380-70-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies
By Anonymous on 01/16/2019
Species: Mouse

VU 591 works to block Inwardly Rectifying Potassium Channels on a few subfamilies.The blocking effect showed by VU 591 is variable on the different classes of Kir channels. Compared to VU 590 which was also used as a reference meausre its blocking action has been found to be on the lower side.Overall acts as a great measure for comparing blocking action.


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