Selective histamine H4
receptor agonist; displays 50-fold selectivity for the rat H4
receptor over the H3
values are 5.75 and 7.46 for rat H3
receptors respectively). Also exhibits affinity for the human H4
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Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Cowart et al.
Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Altenbach et al.
Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach.
Coruzzi et al.