Catalog Number: 4769
Chemical Name: 4-(4-Methyl-1-piperazinyl)-6-phenyl-2-Pyrimidinamine
Biological Activity
Selective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).
Technical Data
  • M.Wt:
    269.34
  • Formula:
    C15H19N5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 2eq.HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1028327-66-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
    Cowart et al.
    J.Med.Chem., 2008;51:6547
  2. Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
    Altenbach et al.
    J.Med.Chem., 2008;51:6571
  3. Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach.
    Coruzzi et al.
    Eur.J.Pharmacol., 2011;669:121
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