WAY 100635 maleate
Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Biological ActivityWAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
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Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Mensonides-Harsema et al.
Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
Zhuang et al.
A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
Forster et al.
WAY-100635 is a potent DA D4 receptor agonist.
Chemel et al.
Psychopharmacology (Berl)., 2006;188:244
Citations for WAY 100635 maleate
The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:
9 Citations: Showing 1 - 9
Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Authors: Nguyen Et al.
Korean J Physiol Pharmacol 2019;23:271
A neural circuit for comorbid depressive symptoms in chronic pain.
Authors: Zhou Et al.
Nat Neurosci 2019;22:1649
Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Authors: Walory Et al.
Int J Mol Sci 2018;19
Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Authors: Rodríguez-Muñoz Et al.
Mol Brain 2018;11:51
Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats.
Authors: Shimizu Et al.
Br J Pharmacol 2017;174:3072
The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
Authors: Wierońska Et al.
Sci Transl Med 2015;232:259
5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Authors: Rawls Et al.
Neurosci Lett 2010;484:113
Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization.
Authors: Greene Et al.
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Used this for validation of a molecular target during behavioral testing in rats. This was used to selectively block central 5-HT1A receptors. Dissolved in water at a dose of 0.5 mg/ ml and 1.0 mg/ml and injected subcutaneously in rats. Injections were followed by behavioral testing.