Potent, silent antagonist of 5-HT1A
= 2.2 nM; Ki
= 0.84 nM for rat 5-HT1A
receptors). Displays 100-fold selectivity for 5-HT1A
over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4
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All Tocris products are intended for laboratory research use only.
Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Mensonides-Harsema et al.
Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
Zhuang et al.
A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
Forster et al.
WAY-100635 is a potent dopamine D4 receptor agonist.
Chemel et al.
Psychopharmacology (Berl)., 2006;188:244
The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:
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