WAY 100635 maleate

  ( 3 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4380
Chemical Name:N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity
Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
Technical Data
  • M.Wt:
    538.64
  • Formula:
    C25H34N4O2.C4H4O4
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    634908-75-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:

3 Citations: Showing 1 - 3
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  1. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
    Authors: Wierońska Et al.
    Sci Transl Med  2015;232:259
  2. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett  2010;484:113
  3. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization.
    Authors: Greene Et al.
    Neuropsychopharmacology  2009;34:2459

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Average Rating: 5 (Based on 1 review)

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  Rat Corinne Kiessling 01/04/2018
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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