Catalog Number: 4380
Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate
Biological Activity
Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.
Technical Data
  • M.Wt:
    538.64
  • Formula:
    C25H34N4O2.C4H4O4
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    634908-75-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
    Mensonides-Harsema et al.
    J.Med.Chem., 2000;43:432
  2. Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2''-pyridinyl)-p-iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.
    Zhuang et al.
    J.Med.Chem., 1994;37:1406
  3. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
    Forster et al.
    Eur.J.Pharmacol., 1995;281:81
  4. WAY-100635 is a potent dopamine D4 receptor agonist.
    Chemel et al.
    Psychopharmacology (Berl)., 2006;188:244
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:

3 Citations: Showing 1 - 3
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  1. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
    Authors: Wierońska Et al.
    Sci Transl Med 2015;232:259
  2. 5-HT(1A)-like receptor activation inhibits abstinence-induced methamphetamine withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett 2010;484:113
  3. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization.
    Authors: Greene Et al.
    Neuropsychopharmacology 2009;34:2459

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