WAY 100635 maleate

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4380/10
4380/50
WAY 100635 maleate | CAS No. 1092679-51-0 | 5-HT1A Receptor Antagonists
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Description: Potent 5-HT1A antagonist; also D4 agonist

Chemical Name: N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products
Reviews (1)

Biological Activity

Potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.

Technical Data

M.Wt:
538.64
Formula:
C25H34N4O2.C4H4O4
Solubility:
Soluble to 25 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1092679-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for WAY 100635 maleate

The citations listed below are publications that use Tocris products. Selected citations for WAY 100635 maleate include:

9 Citations: Showing 1 - 9

  1. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
    Authors: Nguyen Et al.
    Korean J Physiol Pharmacol  2019;23:271
  2. A neural circuit for comorbid depressive symptoms in chronic pain.
    Authors: Zhou Et al.
    Nat Neurosci  2019;22:1649
  3. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
    Authors: Walory Et al.
    Int J Mol Sci  2018;19
  4. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  5. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
    Authors: Yin Et al.
    Cereb Cortex  2017;27:509
  6. Brain serotoninergic nervous system is involved in bombesin-induced frequent urination through brain 5-HT7 receptors in rats.
    Authors: Shimizu Et al.
    Br J Pharmacol  2017;174:3072
  7. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
    Authors: Wierońska Et al.
    Sci Transl Med  2015;232:259
  8. 5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett  2010;484:113
  9. Vascular endothelial growth factor signaling is required for the behavioral actions of antidepressant treatment: pharmacological and cellular characterization.
    Authors: Greene Et al.
    Neuropsychopharmacology  2009;34:2459

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Easy to use, goes into solution well
By Corinne Kiessling on 01/04/2018
Application: Species: Rat

Used this for validation of a molecular target during behavioral testing in rats. This was used to selectively block central 5-HT1A receptors. Dissolved in water at a dose of 0.5 mg/ ml and 1.0 mg/ml and injected subcutaneously in rats. Injections were followed by behavioral testing.


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