WAY 100635 maleate

Tocris Bioscience | Catalog # 4380

Potent 5-HT1A antagonist; also D4 agonist
Tocris Bioscience

Key Product Details

Description

Potent 5-HT1A antagonist; also D4 agonist
View all 5-HT1A Receptor Antagonists »

Product Description

WAY 100635 maleate is a potent, silent antagonist of 5-HT1A receptors (IC50 = 2.2 nM; Ki = 0.84 nM for rat 5-HT1A receptors). Displays 100-fold selectivity for 5-HT1A over other 5-HT subtypes. Also exhibits agonist activity at dopamine D4 receptors.

Product Specifications for WAY 100635 maleate

Molecular Weight

538.64

Formula

C25H34N4O2.C4H4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate

CAS Number

1092679-51-0

PubChem ID

11957721

InChI Key

XIGAHNVCEFUYOV-BTJKTKAUSA-N

SMILES

O=C(C4CCCCC4)N(C3=NC=CC=C3)CCN(CC2)CCN2C1=C(OC)C=CC=C1.O=C(\C=C/C(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.47 25

Preparing Stock Solutions for WAY 100635 maleate

The following data is based on the product molecular weight 538.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 7.43 mL 37.13 mL 74.26 mL
1.25 mM 1.49 mL 7.43 mL 14.85 mL
2.5 mM 0.74 mL 3.71 mL 7.43 mL
12.5 mM 0.15 mL 0.74 mL 1.49 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Product Documents for WAY 100635 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WAY 100635 maleate

For research use only

Citations for WAY 100635 maleate

Customer Reviews for WAY 100635 maleate (1)

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  • Easy to use, goes into solution well
    Name: Corinne Kiessling
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    Used this for validation of a molecular target during behavioral testing in rats. This was used to selectively block central 5-HT1A receptors. Dissolved in water at a dose of 0.5 mg/ ml and 1.0 mg/ml and injected subcutaneously in rats. Injections were followed by behavioral testing.

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