WAY 181187 oxalate

Key Product Details

Product Description

WAY 181187 oxalate is a high affinity and selective 5-HT₆ agonist (K_i = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for WAY 181187 oxalate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WAY 181187 oxalate

The following data is based on the product molecular weight 470.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.24 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Cole Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT₆ receptor agonist. J.Med.Chem. 2007 PMID: 17948978
• Brouard Pharmacological evidence for 5-HT₆ receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 2015 PMID:  25837696

Product Documents for WAY 181187 oxalate