Catalog Number: 3366
Chemical Name: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
Biological Activity
Selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.
Technical Data
  • M.Wt:
    306.11
  • Formula:
    C13H8BrNO3
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    440122-66-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands.
    Malamas et al.
    J.Med.Chem., 2004;47:5021
  2. Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice.
    Clipperton et al.
    Neuropsychopharmacology, 2008;33:2362
  3. WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.
    Hughes et al.
    Neuropharmacology, 2008;54:1136
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WAY 200070 include:

3 Citations: Showing 1 - 3
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  1. Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neurons.
    Authors: Sellers Et al.
    Front Cell Neurosci 2015;9:137
  2. Antidiabetic actions of an estrogen receptor β selective agonist.
    Authors: Alonso-Magdalena Et al.
    PLoS One 2013;62:2015
  3. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
    Authors: Cao Et al.
    J Pain 2012;13:685

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