WAY 200070
Discontinued Product
Chemical Name: 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
Purity: ≥98%
Biological Activity
WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands.
Malamas et al.
J.Med.Chem., 2004;47:5021 -
WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.
Hughes et al.
Neuropharmacology, 2008;54:1136 -
Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice.
Clipperton et al.
Neuropsychopharmacology, 2008;33:2362
Product Datasheets
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Citations for WAY 200070
The citations listed below are publications that use Tocris products. Selected citations for WAY 200070 include:
4 Citations: Showing 1 - 4
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17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
Authors: Oberlander
J Neurosci 2016;36:2677
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Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons.
Authors: Sellers Et al.
Front Cell Neurosci 2015;9:137
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Antidiabetic actions of an estrogen receptor β selective agonist.
Authors: Alonso-Magdalena Et al.
PLoS One 2013;62:2015
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Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
Authors: Cao Et al.
J Pain 2012;13:685
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