Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Biological Activity Potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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