Inhibitor of Wnt/β
-catenin signaling (EC50
~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50
~15 nM); prevents the ubiquitination and degradation of axin.
Soluble to 20 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling.
James et al.
PLoS One, 2012;7:e50457