Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Biological ActivityInhibitor of Wnt/β-catenin signaling (EC 50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC 50 ~15 nM); prevents the ubiquitination and degradation of axin.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling.
James et al.
PLoS One, 2012;7:e50457
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for WIKI4
There are currently no reviews for this product. Be the first to review WIKI4 and earn rewards!
Have you used WIKI4?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image