WIKI4

Catalog # Availability Size / Price Qty
4855/5
4855/25
Cat.No. 4855 - WIKI4 | C29H23N5O3S | CAS No. 838818-26-1
1 Image
Description: Potent tankyrase inhibitor

Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

Purity: ≥98%

Product Details
Reviews

Biological Activity

Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.

Technical Data

M.Wt:
521.59
Formula:
C29H23N5O3S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
838818-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling.
    James et al.
    PLoS One, 2012;7:e50457

Product Datasheets

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