WIKI4

Key Product Details

Product Description

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC₅₀ ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC₅₀ ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

Product Specifications for WIKI4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WIKI4

The following data is based on the product molecular weight 521.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.17 mL	95.86 mL	191.72 mL
0.5 mM	3.83 mL	19.17 mL	38.34 mL
1 mM	1.92 mL	9.59 mL	19.17 mL
5 mM	0.38 mL	1.92 mL	3.83 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• James WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling. PLoS One 2012 PMID: 23227175

Product Documents for WIKI4