Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Biological ActivityWIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).
WIKI4 synthesized to Ancillary Material Grade also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling.
James et al.
PLoS One, 2012;7:e50457
Citation for WIKI4
The citations listed below are publications that use Tocris products. Selected citations for WIKI4 include:
1 Citation: Showing 1 - 1
Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
Authors: Yung Et al.
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