Catalog Number: 4434
Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Biological Activity
Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
Technical Data
  • M.Wt:
    426.15
  • Formula:
    C17H18Br2N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    253449-04-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses.
    Wegner et al.
    J.Biol.Chem., 2008;283:15912
  2. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
    Peterson et al.
    Nat.Struct.Mol.Biol., 2004;11:747
  3. N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.
    Guerriero and Weisz et al.
    Am.J.Physiol.Cell Physiol., 2006;292:C1562
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Wiskostatin include:

1 Citations: Showing 1 - 1

  1. Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF).
    Authors: Rassokhin and Pakhomov
    Cell Biochem Biophys 2014;69:555

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