Chemical Name: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol
Biological ActivityWiskostatin is an inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2-induced actin polymerization (EC50 ~ 4μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses.
Wegner et al.
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Peterson et al.
N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.
Guerriero and Weisz et al.
Am.J.Physiol.Cell Physiol., 2006;292:C1562
Citation for Wiskostatin
The citations listed below are publications that use Tocris products. Selected citations for Wiskostatin include:
1 Citation: Showing 1 - 1
Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF).
Authors: Rassokhin and Pakhomov
Cell Biochem Biophys 2014;69:555
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