Inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP) activity. Interacts with the regulatory GTPase-binding domain of N-WASP; inhibits activation of Arp2/3 complex by maintaining N-WASP in an inactive conformation. Also inhibits PIP2
-induced actin polymerization (EC50
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N-WASP and the Arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses.
Wegner et al.
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Peterson et al.
N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels.
Guerriero and Weisz et al.
Am.J.Physiol.Cell Physiol., 2006;292:C1562
The citations listed below are publications that use Tocris products. Selected citations for Wiskostatin include:
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