WM 1119

Catalog # Availability Size / Price Qty
6692/50
6692/10
Histone Acetyltransferase Inhibitors Small Molecule
1 Image
Description: High affinity KAT6A (MOZ) competitive inhibitor

Chemical Name: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide

Purity: ≥98%

Product Details
Reviews

Biological Activity

High affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM). Displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. Induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). Reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.

Technical Data

M.Wt:
389.38
Formula:
C18H13F2N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2055397-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Monash University

Product Datasheets

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