Chemical Name: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
Biological ActivityWM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.
External Portal InformationChemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Baell et al.
Citation for WM 1119
The citations listed below are publications that use Tocris products. Selected citations for WM 1119 include:
1 Citation: Showing 1 - 1
High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening.
Authors: Jun Et al.
Nat Commun 2020;11:3455
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