Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
Biological ActivityWM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Baell et al.
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