WM 8014

Key Product Details

Product Description

WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC₅₀ values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G₁/G₀ in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.

Licensing Information

Sold under license from Monash University

Product Specifications for WM 8014

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WM 8014

The following data is based on the product molecular weight 384.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.01 mL	65.03 mL	130.07 mL
1 mM	2.60 mL	13.01 mL	26.01 mL
2 mM	1.30 mL	6.50 mL	13.01 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Baell Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 2018 PMID: 30069049

Product Documents for WM 8014