WM 8014

Catalog # Availability Size / Price Qty
6693/10

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WM 8014 | CAS No. 2055397-18-5 | Histone Acetyltransferase Inhibitors
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Description: Potent and selective KAT6A and KAT6B inhibitor

Chemical Name: N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

Purity: ≥98%

Product Details
Reviews

Biological Activity

WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.

Technical Data

M.Wt:
384.42
Formula:
C20H17FN2O3S
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2055397-18-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Monash University

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