Wortmannin

  ( 48 citations )    
Product Datasheet
Catalog Number:1232
Alternate Names:SL-2052
Chemical Name:(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
Product Details
Citations (48)
Reviews
Biological Activity
Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).
Technical Data
  • M.Wt:
    428.44
  • Formula:
    C23H24O8
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Storage:
    Desiccate at -20°C
  • CAS No:
    19545-26-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Wortmannin include:

48 Citations: Showing 1 - 10
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  1. Pancreatic insulin content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells.
    Authors: Sidhar and Giri
    Sci Rep  2017;7:41420
  3. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
    Authors: Maugeri Et al.
    Oncotarget  2016;7:139
  4. Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.
    Authors: Lee Et al.
    Oncotarget  2016;7:11322
  5. The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABAB receptors
    Authors: Olianas Et al.
    European Journal of Pharmacology  2016;794:135
  6. SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination.
    Authors: Wilson Et al.
    Sci Rep  2016;6:17735
  7. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.
    Authors: Ahmed
    Physiological Reports  2016;4:e13069
  8. The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
    Authors: Sahay Et al.
    PLoS One  2015;6:20604
  9. Endothelial Rac1 is essential for hematogenous metastasis to the lung.
    Authors: Yao Et al.
    Sci Rep  2015;6:17501
  10. Stimulation of EphB2 attenuates tau phosphorylation through PI3K/Akt-mediated inactivation of glycogen synthase kinase-3β.
    Authors: Jiang Et al.
    Mol Cancer  2015;5:11765
  11. α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
    Authors: Accardi Et al.
    J Neurosci  2015;35:9676
  12. Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
    Authors: Koutsioumpa Et al.
    Oncotarget  2015;14:19
  13. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    Front Pharmacol  2015;10:e0143319
  14. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci  2014;7:270
  15. Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na.
    Authors: Mäki-Jouppila Et al.
    Nat Commun  2014;13:1054
  16. Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes.
    Authors: Takada Et al.
    J Cell Sci  2014;127:4159
  17. A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
    Authors: Mitrugno Et al.
    Blood  2014;123:249
  18. Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.
    Authors: McAlpine Et al.
    Autophagy  2013;9:361
  19. Combination of LC3 shRNA plasmid transfection and genistein treatment inhibited autophagy and increased apoptosis in malignant neuroblastoma in cell culture and animal models.
    Authors: Mohan Et al.
    PLoS One  2013;8:e78958
  20. Herpes simplex virus 2 (HSV-2) prevents dendritic cell maturation, induces apoptosis, and triggers release of proinflammatory cytokines: potential links to HSV-HIV synergy.
    Authors: Stefanidou Et al.
    Mol Immunol  2013;87:1443
  21. EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity.
    Authors: Choi Et al.
    J Virol  2013;4:2383
  22. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Pharmacol Exp Ther  2013;33:11206
  23. HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression.
    Authors: Cheshenko Et al.
    FASEB J  2013;27:2584
  24. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  25. The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention.
    Authors: Chen Et al.
    BMC Vet Res  2012;8:73
  26. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
    Authors: Villers Et al.
    PLoS One  2012;7:e40823
  27. Endogenous urotensin II selectively modulates erectile function through eNOS.
    Authors: Bianca Et al.
    PLoS One  2012;7:e31019
  28. An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
    Authors: Khurana Et al.
    J Neurosci  2012;32:2814
  29. TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury.
    Authors: Yin Et al.
    J Cell Sci  2012;238:93
  30. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  31. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  32. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model.
    Authors: Liu Et al.
    Am J Physiol Endocrinol Metab  2010;299:E351
  33. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  34. FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
    Authors: Grodzki Et al.
    Exp Neurol  2009;46:2539
  35. Inhibitory effect of ETB receptor on Na(+)-K(+) ATPase activity by extracellular Ca(2+) entry and Ca(2+) release from the endoplasmic reticulum in renal proximal tubule cells.
    Authors: Liu Et al.
    Hypertens Res  2009;32:846
  36. c-jun controls the ability of IL-12 to induce IL-10 production from human memory CD4+ T cells.
    Authors: Garcia Et al.
    J Immunol  2009;183:4475
  37. Antigenic experience dictates functional role of glycogen synthase kinase-3 in human CD4+ T cell responses.
    Authors: Garcia Et al.
    J Immunol  2008;181:8363
  38. Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.
    Authors: Nelson Et al.
    J Neurochem  2008;107:602
  39. IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
    Authors: Chung Et al.
    J Endocrinol  2007;194:77
  40. Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.
    Authors: Rojas Et al.
    Biochim Biophys Acta  2007;1768:2030
  41. PI-3-kinase-dependent membrane recruitment of centaurin-α2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation.
    Authors: Venkateswarlu Et al.
    J Neurosci  2007;120:792
  42. GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
    Authors: Lin Et al.
    J Cell Sci  2007;120:2935
  43. Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum.
    Authors: Bianca Et al.
    J Cell Biochem  2006;316:703
  44. Regulation of nuclear factor κB in the hippocampus by group I metabotropic glutamate receptors.
    Authors: O'Riordan Et al.
    J Neurosci  2006;26:4870
  45. Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.
    Authors: Qiu Et al.
    Mol Cancer Ther  2006;26:12943
  46. Myosin light chain kinase is not a regulator of synaptic vesicle trafficking during repetitive exocytosis in cultured hippocampal neurons.
    Authors: Tokuoka and Goda
    J Neurosci  2006;26:11606
  47. LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II.
    Authors: Searl and Silinsky
    Purinergic Signal  2005;1:389
  48. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.
    Authors: Schlemper Et al.
    Br J Pharmacol  2005;145:740
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