Wortmannin

Tocris Bioscience | Catalog # 1232

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
Tocris Bioscience

Key Product Details

Description

Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Alternative Names

SL-2052
View all Inositol Lipid Inhibitors »

Product Description

Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

Product Specifications for Wortmannin

Molecular Weight

428.44

Formula

C23H24O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(1S,6bR,9aS,11R,11bR) 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione

CAS Number

19545-26-7

PubChem ID

3003565

InChI Key

QDLHCMPXEPAAMD-ZGSWIPFCSA-N

SMILES

O=C(C4=CO5)O[C@H](COC)[C@@]1(C)C4=C5C(C2=C1[C@H](OC(C)=O)C[C@@]3(C)C2CCC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.42 50

Preparing Stock Solutions for Wortmannin

The following data is based on the product molecular weight 428.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.67 mL 23.34 mL 46.68 mL
2.5 mM 0.93 mL 4.67 mL 9.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
25 mM 0.09 mL 0.47 mL 0.93 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 308 publications citing the usage of this product.

Product Documents for Wortmannin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Wortmannin

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Wortmannin (2)

4.5 out of 5
2 Customer Ratings
5 Stars
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4 Stars
50%
3 Stars
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2 Stars
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1 Stars
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  • Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 02/03/2020
    10nM Wortmannin
    Wortmannin 1232
  • Inhibition of autophagy before immunocytochemistry in human fibroblasts
    Name: tom stoker
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 09/17/2018
    Treatment of fibroblasts for 4 hours prior to staining for LC3 and P62.
    Wortmannin 1232

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