WRW4

  ( 6 citations )    
Product Datasheet
Catalog Number:2262
Alternate Names:WRW4
Chemical Name:
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
Technical Data
  • M.Wt:
    1104.28
  • Formula:
    C61H65N15O6
  • Sequence:
    WRWWWW

    (Modifications: Trp-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    878557-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for WRW4 include:

6 Citations: Showing 1 - 6
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  1. Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome.
    Authors: Wenceslau Et al.
    Am J Physiol Heart Circ Physiol  2015;308:H768
  2. Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1.
    Authors: Hasan Et al.
    BMC Mol Biol  2014;18:497
  3. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.
    Authors: Tristão Et al.
    Infect Immun  2013;81:1256
  4. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
    Authors: Barnig Et al.
    Sci Transl Med  2013;5:174ra26
  5. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest  2013;123:443
  6. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.
    Authors: Khau Et al.
    Korean J Physiol Pharmacol  2011;25:483

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