Catalog Number: 2262
Alternate Names: WRW4
Biological Activity
Selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
Technical Data
  • M.Wt:
    1104.28
  • Formula:
    C61H65N15O6
  • Sequence:
    WRWWWW

    (Modifications: Trp-6 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    878557-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling.
    Bae et al.
    J.Immunol., 2004;173:607
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WRW4 include:

5 Citations: Showing 1 - 5
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  1. Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1.
    Authors: Hasan Et al.
    BMC Mol Biol 2014;18:497
  2. 5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.
    Authors: Tristão Et al.
    Infect Immun 2013;81:1256
  3. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
    Authors: Barnig Et al.
    Sci Transl Med 2013;5:174ra26
  4. Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
    Authors: Leoni Et al.
    J Clin Invest 2013;123:443
  5. Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.
    Authors: Khau Et al.
    Korean J Physiol Pharmacol 2011;25:483

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