WRW4

Tocris Bioscience | Catalog # 2262

Selective FPR2 antagonist
Tocris Bioscience

Key Product Details

Description

Selective FPR2 antagonist

Alternative Names

WRW4
View all Formyl Peptide Receptor Antagonists »

Product Description

WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.

Product Specifications for WRW4

Molecular Weight

1104.28

Formula

C61H65N15O6

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

878557-55-2

PubChem ID

49768327

InChI Key

IRJDOVLLPORVJP-WOAIKHIASA-N

SMILES

[H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 78 publications citing the usage of this product.

Product Documents for WRW4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WRW4

For research use only

Customer Reviews for WRW4 (1)

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  • it's ok
    Name: Christopher Durrant
    Species: Human
    Assay Type: Ex Vivo
    Verified Customer | Posted 01/09/2020
    Followed publication, it worked, great
    for formyl peptide receptor 2 (FPR2) signaling

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