Biological ActivityWRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. Inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and inhibits intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Also inhibits FPR2-mediated signaling in human neutrophils; blocks chemotactic migration and superoxide generation by amyloid β42 peptide.
(Modifications: Trp-6 = C-terminal amide)
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Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling.
Bae et al.
Citations for WRW4
The citations listed below are publications that use Tocris products. Selected citations for WRW4 include:
8 Citations: Showing 1 - 8
The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
Authors: Cussell Et al.
PLoS One 2019;14:e0217815
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.
Authors: Rhys Et al.
Mitochondrial N-formyl peptides induce cardiovascular collapse and sepsis-like syndrome.
Authors: Wenceslau Et al.
Am J Physiol Heart Circ Physiol 2015;308:H768
Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1.
Authors: Hasan Et al.
BMC Mol Biol 2014;18:497
5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.
Authors: Tristão Et al.
Infect Immun 2013;81:1256
Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma.
Authors: Barnig Et al.
Sci Transl Med 2013;5:174ra26
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
Authors: Leoni Et al.
J Clin Invest 2013;123:443
Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2.
Authors: Khau Et al.
Korean J Physiol Pharmacol 2011;25:483
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for formyl peptide receptor 2 (FPR2) signaling