Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Biological ActivityPotent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators.
Beck et al.
Cell Calcium, 2007;41:285
Characterisation of TRPM8 as a pharmacophore receptor.
Bodding et al.
Cell Calcium, 2007;42:618
Citations for WS 12
The citations listed below are publications that use Tocris products. Selected citations for WS 12 include:
2 Citations: Showing 1 - 2
Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Authors: Morgan Et al.
Biosci Rep 2015;35
TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
Authors: Liu Et al.
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WS12 was used to activate TRPM8 currents in dorsal root ganglia neurons through whole cell mode patch clamp.
TRP Ion channel, TRPM8 agonist in in vivo experiments in mouse and in vitro tissue, especially Mouse Mesenteric artery to check change in arterial diameter.