WS 12

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3040/10
3040/50
WS 12 | CAS No. 68489-09-8 | TRPM Agonists
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Description: TRPM8 agonist; cooling agent

Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews (2)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

Technical Data

M.Wt:
289.41
Formula:
C18H27NO2
Solubility:
Soluble to 75 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
68489-09-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators.
    Beck et al.
    Cell Calcium, 2007;41:285
  2. Characterisation of TRPM8 as a pharmacophore receptor.
    Bodding et al.
    Cell Calcium, 2007;42:618

Product Datasheets

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Citations for WS 12

The citations listed below are publications that use Tocris products. Selected citations for WS 12 include:

2 Citations: Showing 1 - 2

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Activation of TRPM8 currents
By Anonymous on 01/18/2018
Species: Rat

WS12 was used to activate TRPM8 currents in dorsal root ganglia neurons through whole cell mode patch clamp.


WS12 as selective TRPM8 agonist and better than menthol.
By Hiteshkumar Soni on 01/10/2018
Species: Mouse

TRP Ion channel, TRPM8 agonist in in vivo experiments in mouse and in vitro tissue, especially Mouse Mesenteric artery to check change in arterial diameter.


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