WS 12

Tocris Bioscience | Catalog # 3040

TRPM8 agonist; cooling agent
Tocris Bioscience

Key Product Details

Description

TRPM8 agonist; cooling agent
View all TRPM Agonists »

Product Description

WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

Product Specifications for WS 12

Molecular Weight

289.41

Formula

C18H27NO2

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

(1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide

CAS Number

68489-09-8

PubChem ID

11266244

InChI Key

HNSGVPAAXJJOPQ-XOKHGSTOSA-N

SMILES

C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 21.71 75

Preparing Stock Solutions for WS 12

The following data is based on the product molecular weight 289.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.61 mL 23.04 mL 46.07 mL
3.75 mM 0.92 mL 4.61 mL 9.21 mL
7.5 mM 0.46 mL 2.30 mL 4.61 mL
37.5 mM 0.09 mL 0.46 mL 0.92 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

Product Documents for WS 12

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for WS 12

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for WS 12 (2)

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  • Activation of TRPM8 currents
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Verified Customer | Posted 01/18/2018
    WS12 was used to activate TRPM8 currents in dorsal root ganglia neurons through whole cell mode patch clamp.
  • WS12 as selective TRPM8 agonist and better than menthol.
    Name: Hiteshkumar Soni
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: Mouse Mesenteric artery
    Verified Customer | Posted 01/10/2018
    TRP Ion channel, TRPM8 agonist in in vivo experiments in mouse and in vitro tissue, especially Mouse Mesenteric artery to check change in arterial diameter.
    WS 12 3040

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