Chemical Name: N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl carbamic acid ester
Biological ActivityPotent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol.
Blankman et al.
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.
Li et al.
Citation for WWL 70
The citations listed below are publications that use Tocris products. Selected citations for WWL 70 include:
1 Citation: Showing 1 - 1
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury.
Authors: Tchantchou and Zhang
J Neurotrauma 2013;30:565
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