2-Arachidonylglycerol

Tocris Bioscience | Catalog # 1298

Endogenous and non-selective CB agonist; potent GPR55 agonist
Tocris Bioscience

Key Product Details

Description

Endogenous and non-selective CB agonist; potent GPR55 agonist

Alternative Names

2-AG,Arachidonoylglycerol
View all Non-selective Cannabinoid Receptor Agonists »

Product Description

2-Arachidonylglycerol is a endogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC50 values are 3, 519 and 618 nM at GPR55, CB1 and CB2 respectively; Ki values are 472 and 1400 nM at CB1 and CB2 respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide. Effects are enhanced by combined administration with 2-palmitoylglycerol (Cat. No. 2206) in vivo. Also antagonizes bacterial quorum sensing receptor QseC. Protects mice from enteric infection by Enterobacteriaceae pathogens.

Product Specifications for 2-Arachidonylglycerol

Molecular Weight

378.55

Formula

C23H38O4

Storage

Store at -80°C

Chemical Name

(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester

CAS Number

53847-30-6

PubChem ID

5282280

InChI Key

RCRCTBLIHCHWDZ-DOFZRALJSA-N

SMILES

O=C(OC(CO)CO)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.85 100
Ethanol 37.85 100

Preparing Stock Solutions for 2-Arachidonylglycerol

The following data is based on the product molecular weight 378.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for 2-Arachidonylglycerol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 2-Arachidonylglycerol

For research use only

Citations for 2-Arachidonylglycerol

Customer Reviews for 2-Arachidonylglycerol (1)

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  • Great product
    Name: Kevin Lorch
    Species: Escherichia coli
    Assay Type: In Vivo
    Verified Customer | Posted 10/05/2022
    Used in a bacterial signaling assay to screen for potential sensors of 2-arachidonylglycerol. Very easy to work with, non-toxic to E. coli even at concentrations up to 1 mg/mL. Planning to reorder for some follow-up experiments. Only downside is having to store at -80C.

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