2-Arachidonylglycerol

  ( 13 citations )    
Product Datasheet
Catalog Number:1298
Alternate Names:2-AG, Arachidonoylglycerol
Chemical Name:(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Endogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC50 values are 3, 519 and 618 nM at GPR55, CB1 and CB2 respectively; Ki values are 472 and 1400 nM at CB1 and CB2 respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide. Effects are enhanced by combined administration with 2-palmitoylglycerol (Cat. No. 2206) in vivo.
Technical Data
  • M.Wt:
    378.55
  • Formula:
    C23H38O4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Storage:
    Store at -80°C
  • CAS No:
    53847-30-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 2-Arachidonylglycerol include:

13 Citations: Showing 1 - 10
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  1. Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors.
    Authors: Nogueras-Ortiz
    Mol Biol Cell  2017;28(24):3554
  2. Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
    Authors: Mounsey Et al.
    Pharmacol Res  2015;273:36
  3. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1.
    Authors: Flores-Otero Et al.
    Nat Commun  2014;5:4589
  4. Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans.
    Authors: Lin Et al.
    Aging Cell  2014;13:755
  5. Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids.
    Authors: Higgins Et al.
    Mol Pain  2013;9:26
  6. The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
    Authors: Valdeolivas Et al.
    Br J Pharmacol  2013;4:e862
  7. Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene.
    Authors: Chanda Et al.
    J Cell Biol  2012;287:38041
  8. Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.
    Authors: Khasabova Et al.
    J Biol Chem  2011;64:60
  9. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
    Authors: Yuan and Burrell
    J Neurophysiol  2010;104:2766
  10. Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells.
    Authors: Carney Et al.
    J Neuroimmune Pharmacol  2009;4:338
  11. Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
    Authors: Wang Et al.
    Stroke  2009;40:2157
  12. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
    Authors: Ho and Randall
    Exp Neurol  2007;150:641
  13. The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response.
    Authors: Williams Et al.
    Proc Natl Acad Sci U S A  2003;160:481
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