WZ 4003

   
Product Datasheet
Catalog Number:5177
Chemical Name:N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide
Product Details
Reviews
Biological Activity
Potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100 nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WZ 4003 is reviewed on the chemical probes website.
Technical Data
  • M.Wt:
    496.99
  • Formula:
    C25H29ClN6O3
  • Solubility:
    Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    1214265-58-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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