WZB 117

Key Product Details

Product Description

WZB 117 is a GLUT inhibitor (K_i(app) values are 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively). Competitive inhibitor of net glucose uptake but a noncompetitive inhibitor of sugar efflux from cells. Inhibits passive sugar transport in human erythrocytes and cancer cell lines. Attenuates erythrocyte 3-O-methylglucose (3MG) uptake in vitro (K_i = 6 μM). Suppresses tumor growth in a nude mouse model.

Product Specifications for WZB 117

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for WZB 117

The following data is based on the product molecular weight 368.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.58 mL	27.15 mL
5 mM	0.54 mL	2.72 mL	5.43 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Liu A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol.Cancer Ther. 2012 PMID: 22689530
• Koch Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells. Oncotarget 2015 PMID: 26293674
• Ojelabi WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) inhibits GLUT1-mediated sugar transport by binding reversibly at the exofacial sugar binding site. J.Biol.Chem. 2016 PMID: 27836974

Product Documents for WZB 117