Xamoterol hemifumarate

  ( 8 citations )    
Product Datasheet
Catalog Number:0950
Alternate Names:ICI 118,587
Chemical Name:1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
Product Details
Citations (8)
Supplemental Products
Reviews
Biological Activity
β1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at β1- and β2-adrenoceptors respectively).
Technical Data
  • M.Wt:
    397.43
  • Formula:
    C16H25N3O5.0.5C4H4O4
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at RT
  • CAS No:
    73210-73-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Xamoterol hemifumarate include:

8 Citations: Showing 1 - 8
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  1. β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
    Authors: Lavine
    Invest Ophthalmol Vis Sci  2017;58(1):299
  2. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
    Authors: Creed Et al.
    Breast Cancer Res  2015;17:145
  3. Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
    Authors: Copik Et al.
    J Pharmacol Exp Ther  2015;10:e0115701
  4. Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
    Authors: Lavine Et al.
    JAMA Ophthalmol  2013;131:376
  5. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
    Authors: Rankovic Et al.
    PLoS One  2011;6:e27474
  6. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J  2011;25:4486
  7. β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.
    Authors: Steinle Et al.
    PLoS One  2003;278:20681
  8. Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes.
    Authors: Skeberdis Et al.
    Br J Pharmacol  1997;121:1277

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