XL 413 hydrochloride

Key Product Details

Product Description

XL 413 hydrochloride is a potent and selective Cdc7 inhibitor (IC₅₀ = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. XL 413 also improves homology-directed repair (HDR) editing in hematopoietic stem cells (HSC).

Product Specifications for XL 413 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for XL 413 hydrochloride

The following data is based on the product molecular weight 326.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.33 mL	76.64 mL	153.29 mL
1 mM	3.07 mL	15.33 mL	30.66 mL
2 mM	1.53 mL	7.66 mL	15.33 mL
10 mM	0.31 mL	1.53 mL	3.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Koltun Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg.Med.Chem.Lett. 2012 PMID: 22560567
• Azhagiri Homology-directed gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. Stem Cell Res.Ther. 2021 PMID: 34503562
• Sasi The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS ONE 2014 PMID: 25412417

Product Documents for XL 413 hydrochloride