XMU MP 1
Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
Biological ActivityXMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
Fan et al.
Therapy: Targeting liver tissue repair and regeneration.
Ray et al.
Regenerative medicine: Inhibiting Hippo repairs tissue.
Crunkhorn et al.
Nat.Rev.Drug Discov., 2016;15:678
Citation for XMU MP 1
The citations listed below are publications that use Tocris products. Selected citations for XMU MP 1 include:
1 Citation: Showing 1 - 1
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.
Authors: Turunen Et al.
Cell Death Differ 2019;
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