Catalog # Availability Size / Price Qty
XMU MP 1 | CAS No. 2061980-01-4 | Other Kinase Inhibitors
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Description: Potent and selective MST1/2 inhibitor; orally bioavailable

Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide

Purity: ≥98%

Product Details
Citations (5)

Biological Activity

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
    Fan et al.
    Sci.Transl.Med., 2016;8:352
  2. Therapy: Targeting liver tissue repair and regeneration.
    Ray et al.
    Nat.Rev.Gastroenterol.Hepatol., 2016;13:559
  3. Regenerative medicine: Inhibiting Hippo repairs tissue.
    Crunkhorn et al.
    Nat.Rev.Drug Discov., 2016;15:678

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Citations for XMU MP 1

The citations listed below are publications that use Tocris products. Selected citations for XMU MP 1 include:

5 Citations: Showing 1 - 5


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