XMU MP 1

Tocris Bioscience | Catalog # 6482

Potent and selective MST1/2 inhibitor; orally bioavailable
Tocris Bioscience

Key Product Details

Description

Potent and selective MST1/2 inhibitor; orally bioavailable
View all Other Kinase Inhibitors »

Product Description

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Product Specifications for XMU MP 1

Molecular Weight

416.48

Formula

C17H16N6O3S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide

CAS Number

2061980-01-4

PubChem ID

121499143

InChI Key

YRDHKIFCGOZTGD-UHFFFAOYSA-N

SMILES

CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.65 100

Preparing Stock Solutions for XMU MP 1

The following data is based on the product molecular weight 416.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.40 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.40 mL 4.80 mL
10 mM 0.24 mL 1.20 mL 2.40 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for XMU MP 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for XMU MP 1

For research use only

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