Catalog # Availability Size / Price Qty
Cat.No. 6482 - XMU MP 1 | C17H16N6O3S2 | CAS No. 2061980-01-4
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Description: Potent and selective MST1/2 inhibitor; orally bioavailable

Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide

Product Details

Biological Activity

Potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). manner. Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

Technical Data

Soluble to 100 mM in DMSO
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration.
    Fan et al.
    Sci.Transl.Med., 2016;8:352
  2. Therapy: Targeting liver tissue repair and regeneration.
    Ray et al.
    Nat.Rev.Gastroenterol.Hepatol., 2016;13:559
  3. Regenerative medicine: Inhibiting Hippo repairs tissue.
    Crunkhorn et al.
    Nat.Rev.Drug Discov., 2016;15:678

Product Datasheets

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