Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
Biological ActivityNitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4
Teixeira et al.
YC-1, a novel activator of platelet guanylate cyclase.
Ko et al.
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Martin et al.
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
Wang et al.
Citations for YC 1
The citations listed below are publications that use Tocris products. Selected citations for YC 1 include:
2 Citations: Showing 1 - 2
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart dFdCyd Resistance to Pancreatic Cancer.
Authors: Shukla Et al.
Cancer Cell 2017;32:71
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Authors: Bellamy and Garthwaite
Br J Pharmacol 2002;136:95
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