YC 1

Catalog # Availability Size / Price Qty
4307/10
4307/50
Cat.No. 4307 - YC 1 | C19H16N2O2 | CAS No. 170632-47-0
1 Image
Description: Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Technical Data

M.Wt:
304.34
Formula:
C19H16N2O2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
170632-47-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for YC 1

The citations listed below are publications that use Tocris products. Selected citations for YC 1 include:

1 Citation: Showing 1 - 1

  1. Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
    Authors: Bellamy and Garthwaite
    Br J Pharmacol  2002;136:95

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