Catalog Number: 4307
Chemical Name: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole
Biological Activity
Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells.
    Wang et al.
    J.Pharmacol.Exp.Ther., 2005;312:917
  2. YC-1, a novel activator of platelet guanylate cyclase.
    Ko et al.
    Blood., 1994;84:4226
  3. YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
    Martin et al.
    Proc.Natl.Sci.U.S.A., 2001;98:12938
  4. Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4
    Teixeira et al.
    J.Pharmacol.Exp.Ther., 2006;317:258
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