GPR35 agonist (EC50
= 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC50
= 10.2 μ
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All Tocris products are intended for laboratory research use only.
Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.
Deng et al.