YH 239-EE

Tocris Bioscience | Catalog # 6719

Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
Tocris Bioscience
Discontinued Product
6719 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description

Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor; activates p53 activity
View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

YH 239-EE is a MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.

Product Specifications for YH 239-EE

Molecular Weight

504.41

Formula

C25H27Cl2N3O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate

CAS Number

1364488-67-4

PubChem ID

56943013

InChI Key

OTUBDDRFPQLPKD-UHFFFAOYSA-N

SMILES

CCOC(C1=C(C2=CC=C(C=C2N1)Cl)C(C(NC(C)(C)C)=O)N(C=O)CC3=CC=C(C=C3)Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.44 100
Ethanol 10.09 20

Preparing Stock Solutions for YH 239-EE

The following data is based on the product molecular weight 504.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.98 mL 9.91 mL 19.83 mL
5 mM 0.40 mL 1.98 mL 3.97 mL
10 mM 0.20 mL 0.99 mL 1.98 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for YH 239-EE

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for YH 239-EE

For research use only

Related Research Areas

E3 Ubiquitin Ligases

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