Chemical Name: Ethyl 3-[2-(tert-butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
Biological ActivityYH 239-EE is a MDM2 inhibitor. Disrupts MDM2-p53 and activates p53 activity in vitro. Prevents mitotic catastrophe and promotes survival of aged muscle stem cells (muSCs). Also inhibits proliferation of AML cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.
Huang et al.
ACS Chem.Biol., 2014;9:802
Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells.
Liu et al.
Cell Stem Cell., 2018;23:544
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