YIL 781 hydrochloride
Chemical Name: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
Biological ActivityGhrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.
Esler et al.
Gut peptides: targets for antiobesity drug development?
Moran and Dailey
Citations for YIL 781 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for YIL 781 hydrochloride include:
3 Citations: Showing 1 - 3
Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.
Authors: T?th Et al.
G Protein and β-arrestin signaling bias at the ghrelin receptor.
Authors: Evron Et al.
J Biol Chem 2014;289:33442
Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion.
Authors: Song Et al.
PLoS One 2013;8:e65422
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for YIL 781 hydrochloride
There are currently no reviews for this product. Be the first to review YIL 781 hydrochloride and earn rewards!
Have you used YIL 781 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image