Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Biological ActivityInhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma.
Erkizan et al.
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