YM 022

Key Product Details

Product Description

YM 022 is an extremely potent and highly selective non-peptide CCK₂ silent antagonist (K_i values are 68 pM and 63 nM at CCK₂ and CCK₁ receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.

Product Specifications for YM 022

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for YM 022

The following data is based on the product molecular weight 516.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.68 mL	19.36 mL
5 mM	0.39 mL	1.94 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 54 publications citing the usage of this product.

• Kitano Long-lasting cholecystokinin₂ receptor blockade after a single subcutaneous injection of YF476 or YM022. Br.J.Pharmacol. 2000 PMID: 10821801
• Nishida Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro J.Pharmacol.Exp.Ther. 1994 PMID: 7910212
• Beinborn Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones. Yale J.Biol.Med. 1998 PMID: 10461364

Product Documents for YM 022