YM 254890

Tocris Bioscience | Catalog # 7352

Gα-protein inhibitor; potent inhibitor of Gq/11 signaling
Tocris Bioscience

Key Product Details

Description

Gα-protein inhibitor; potent inhibitor of Gq/11 signaling
View all GTPase Inhibitors »

Product Description

YM 254890 is a Gα-protein inhibitor. Potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol-induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP-induced Ca2+ increase in platelets, in vitro (IC50 = 2 μM). Also inhibits Gs-induced cAMP elevation and G protein-coupled MAPK/ERK signaling.

Product Specifications for YM 254890

Molecular Weight

960.09

Formula

C46H69N7O15

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(R)-1-((3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2S,3R)-2-acetamido-3-hydroxy-4-methylpentanoate

CAS Number

568580-02-9

PubChem ID

9919454

InChI Key

QVYLWCAYZGFGNF-WBWCVGBTSA-N

SMILES

[H][C@]1(N(C([C@H]([C@@H](C(C)C)OC([C@H]([C@@H](C(C)C)O)NC(C)=O)=O)NC([C@@H](N(C([C@@H](NC(C(N(C([C@H](OC([C@H]([C@H](OC1=O)C)NC(C)=O)=O)CC2=CC=CC=C2)=O)C)=C)=O)C)=O)C)C)=O)=O)C)[C@H](OC)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.6 10

Preparing Stock Solutions for YM 254890

The following data is based on the product molecular weight 960.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.42 mL 52.08 mL 104.16 mL
0.5 mM 2.08 mL 10.42 mL 20.83 mL
1 mM 1.04 mL 5.21 mL 10.42 mL
5 mM 0.21 mL 1.04 mL 2.08 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

Product Documents for YM 254890

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for YM 254890

For research use only

Related Research Areas

Epithelial Cell Polarity

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