YM 26734

Catalog # Availability Size / Price Qty
2522/10
YM 26734 | CAS No. 144337-18-8 | Phospholipase Inhibitors
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Description: Secretory phospholipase A2 (sPLA2) inhibitor

Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

Purity: ≥95%

Product Details
Citations (2)
Reviews

Biological Activity

Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Technical Data

M.Wt:
730.97
Formula:
C45H62O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
144337-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for YM 26734

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