YM 26734

  ( 2 citations )    
Product Datasheet
Catalog Number:2522
Chemical Name:1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
Product Details
Citations (2)
Reviews
Biological Activity
Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
Technical Data
  • M.Wt:
    730.97
  • Formula:
    C45H62O8
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >95
  • Storage:
    Store at -20°C
  • CAS No:
    144337-18-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for YM 26734 include:

2 Citations: Showing 1 - 2
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  1. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun  2014;5:5105
  2. Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
    Authors: Bianca Et al.
    Front Mol Neurosci  2010;161:1835

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