Catalog Number: 2522
Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
Biological Activity
Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2.
    Miyake et al.
    Br.J.Pharmacol., 1993;110:447
  2. Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages.
    Miyake et al.
    Eur.J.Pharmacol., 1994;253:155
  3. Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation.
    Hamaguchi et al.
    Biochim.Biophys.Acta, 2003;1635:37

The citations listed below are publications that use Tocris products. Selected citations for YM 26734 include:

Showing Results 1 - 2 of 2

  1. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun
  2. Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
    Authors: Bianca Et al.
    Front Mol Neurosci
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